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20002025

Research activity per year

Personal profile

Professional experience

1999.9.-present Professor, Seoul National University
2004.6.-2005.5. Research Associate, National Institutes of Health(United States)
2003.6.-2005.5. Special Volunteer/Research Fellow, National Institutes of Health(United States)

Research Interests

1. The digital planning in orthognathic surgery
2. Long term follow ups in the clinical cases of orthognathic surgery
3. Maxillofacial cysts

Key Words: Digital surgical planning; orthognathic surgery; long term follow up
Publication / Patent

Major Research Achievements

1. Myoung H, Hong SP, Hong SD, Lee JI, Lim CY, Choung PH, Lee JH, Choi JY, Seo BM, Kim MJ. Odontogenic keratocyst: Review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Mar;91(3):328-33
2. Choung PH, Seo BM, Chung CP, Yamada KM, Jang JH. Synergistic activity of fibronectin and fibroblast growth factor receptors on neuronal adhesion and neurite extension through ERK pathway. Biochem Biophys Res Commun, 2002, 295:898-902.
3. Oh JE, Kook JK, Park KH, Lee G, Seo BM, Min BM. Phospholipase C-gamma1 is required for subculture-induced terminal differentiation of normal human oral keratinocytes. Int J Mol Med. 2003 Apr;11(4):491-8
4. Chung JH, Park KH, Seo BM, Kim ES, Hong JR, Chung IH, Kang N, Baek JH, Min BM, Choung YH, Akaike T, Choung PH. Determination of specific interactions between glucose ligand carrying polymer and glucose transporter type-1 (GLUT-1) using different cell types. J Biomed Mater Res. 2003, 67A:1055-9.
5. Seo BM, Miura M, Gronthos S, Bartold PP, Batouli S, Brahim J, Young M, Robey PG, Wang PC, Shi S. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 2004, 364:149-5
6. Miura M, Chen XD, Allen MR, Bi Y, Gronthos S, Seo BM, Lakhani S, Flavell RA, Feng XH, Robey PG, Young M, Shi S. A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells. J Clin Invest. 2004, 114:1704-13.
7. Lee JH, Kim MJ, Choi WS, Yoon PY, Ahn KM, Myung H, Hwang SJ, Seo BM, Choi JY, Choung PH, Kim SM. Concomitant reconstruction of mandibular basal and alveolar bone with a free fibular flap. Int J Oral Maxillofac Surg. 2004;33:150-6.
8. Seo BM, Miura M, Sonoyama W, Coppe C, Stanyon R, Shi S. Recovery of stem cells from cryopreserved periodontal ligament. J Dent Res. 2005, 84:907-912 (IF 3.475)
9. Shi S, Bartold PM, Miura M, Seo BM, Robey PG, Gronthos S. The efficacy of mesenchymal stem cells to regenerate and repair dental structures. Orthod Craniofacial Res. 2005, 8:191-9
10. Sonoyama W, Liu Y, Fang D, Yamaza T, Seo BM, Zhang C, Liu H, Gronthos S, Wang CY, Shi S, Wang S. Mesenchymal stem cell-mediated functional tooth regeneration in Swine. PLoS ONE. 2006 Dec 20;1:e79.
11. Miura Y, Gao Z, Miura M, Seo BM, Sonoyama W, Chen W, Gronthos S, Zhang L, Shi S. Mesenchymal stem cell-organized bone marrow elements: an alternative hematopoietic progenitor resource. Stem Cells. 2006 Nov;24(11):2428-36.(IF 7.924)
12. Miura M, Miura Y, Padilla-Nash HM, Molinolo AA, Fu B, Patel V, Seo BM, Sonoyama W, Zheng JJ, Baker CC, Chen W, Ried T, Shi S. Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation.Stem Cells. 2006 Apr;24(4):1095-103.(IF 7.924)
13. Rho KS, Jeong L, Lee G, Seo BM, Park YJ, Hong SD, Roh S, Cho JJ, Park WH, Min BM. Electrospinning of collagen nanofibers: Effects on the behavior of normal human keratinocytes and early-stage wound healing. Biomaterials. 2006, 27(8):1452-61
14. Fang D, Seo BM, Liu Y, Sonoyama W, Yamaza T, Zhang C, Wang S, Shi S.Transplantation of mesenchymal stem cells is an optimal approach for plastic surgery. Stem Cells. 2007 Apr;25(4):1021-8. Epub 2006 Dec 14. (IF 7.924)
15. Bi Y, Ehirchiou D, Kilts TM, Inkson CA, Embree MC, Sonoyama W, Li L, Leet AI, Seo BM, Zhang L, Shi S, Young MF. Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nat Med. 2007 Oct;13(10):1219-27. Epub 2007 Sep 9 (IF 28.588)
16. Sonoyama W, Seo BM, Yamaza T, Shi S. Human Hertwig's epithelial root sheath cells play crucial roles in cementum formation. J Dent Res. 2007 Jul;86(7):594-9. (IF 3.475)
17. Hong J, Yun PY, Chung IH, Myoung H, Suh JD, Seo BM, Lee JH, Choung PH. Long-term follow up on recurrence of 305 ameloblastoma cases. Int J Oral Maxillofac Surg. 2007 Apr;36(4):283-8. Epub 2007 Jan 11. (IF 1.212)
18. Hong J, Yun PY, Chung IH, Myoung H, Suh JD, Seo BM, Lee JH, Choung PH. Long-term follow up on recurrence of 305 ameloblastoma cases. Int J Oral Maxillofac Surg. 2007 Apr;36(4):283-8. (IF 1.212)
19. Kim JW, Lee SK, Lee ZH, Park JC, Lee KE, Lee MH, Park JT, Seo BM, Hu JC, Simmer JP. FAM83H mutations in families with autosomal-dominant hypocalcified amelogenesis imperfecta. Am J Hum Genet. 2008 Feb;82(2):489-94.
20. Hyun HK, Lee SJ, Ahn BD, Lee ZH, Heo MS, Seo BM, Kim JW. Nonsyndromic multiple mandibular supernumerary premolars. J Oral Maxillofac Surg. 2008 Jul;66(7):1366-9.
21. Seo BM, Sonoyama W, Yamaza T, Coppe C, Kikuiri T, Akiyama K, Lee JS, Shi S. SHED repair critical-size calvarial defects in mice. Oral Dis. 2008 Jul;14(5):428-34.
22. Kim SH, Kim KH, Seo BM, Koo KT, Kim TI, Seol YJ, Ku Y, Rhyu IC, Chung CP, Lee YM. Alveolar bone regeneration by transplantation of periodontal ligament stem cells and bone marrow stem cells in a canine peri-implant defect model: a pilot study. J Periodontol. 2009 Nov;80(11):1815-23.
23. Kim SH,Seo BM, Choung PH, Lee YM. Adult stem cell therapy for periodontal disease Int J Stem Cells. 2010 May;3(1):16-21.
24. Heo YY, Um S, Kim SK, Park JM, Seo BM. Responses of periodontal ligament stem cells on various titanium surfaces. Oral Dis. 2011 Apr;17(3):320-7.
25. Nam H, Kim J, Park J, Park JC, Kim JW, Seo BM, Lee JC, Lee G. Expression profile of the stem cell markers in human Hertwig's epithelial root sheath/Epithelial rests of Malassez cells. Mol Cells. 2011 Apr;31(4):355-60.
26. Jung HS, Lee DS, Lee JH, Park SJ, Lee G,Seo BM, Ko JS, Park JC. Directing the differentiation of human dental follicle cells into cementoblasts and/or osteoblasts by a combination of HERS and pulp cells. J Mol Histol. 2011 Jun;42(3):227-35.
27. Um S, Choi JR, Lee JH, Zhang Q, Seo BM. Effect of leptin on differentiation of human dental stem cells. Oral Dis. 2011 Oct;17(7):662-9.
28. Lee JH, Lee DS, Choung HW, Shon WJ,Seo BM, Lee EH, Cho JY, Park JC. Odontogenic differentiation of human dental pulp stem cells induced by preameloblast-derived factors. Biomaterials. 2011 Dec;32(36):9696-706.
29. Lee JH, Lee DS, Nam H, Lee G,Seo BM, Cho YS, Bae HS, Park JC. Dental follicle cells and cementoblasts induce apoptosis of ameloblast-lineage and Hertwig's epithelial root sheath/epithelial rests of Malassez cells through the Fas-Fas ligand pathway. Eur J Oral Sci. 2012 Feb;120(1):29-37.
30. Lee JH, Um S, Jang JH,Seo BM. Effects of VEGF and FGF-2 on proliferation and differentiation of human periodontal ligament stem cells. Cell Tissue Res. 2012 Jun;348(3):475-84.
31. Suh HY, Lee SJ, Lee YS, Donatelli RE, Wheeler TT, Kim SH, Eo SH,Seo BM. A more accurate method of predicting soft tissue changes after mandibular setback surgery. J Oral Maxillofac Surg. 2012 Oct;70(10):e553-62.
32. Lee JH, Nam H, Um S, Lee J, Lee G,Seo BM. Upregulation of GM-CSF by TGF-1 in epithelial mesenchymal transition of human HERS/ERM cells. In Vitro Cell Dev Biol Anim. 2014;50(5):399-405.
33. Nam H, Kim JH, Kim JW,Seo BM, Park JC, Kim JW, Lee G. Establishment of Hertwig's epithelial root sheath/epithelial rests of Malassez cell line from human periodontium. Mol Cells. 2014 Jul;37(7):562-7.
34. Lee JH, Um S, Song IS, Kim HY,Seo BM. Neurogenic differentiation of human dental stem cells in vitro. J Korean Assoc Oral Maxillofac Surg. 2014 Aug;40(4):173-80.
35. Qadir AS, Um S, Lee H, Baek K,Seo BM, Lee G, Kim GS, Woo KM, Ryoo HM, Baek JH. miR-124 negatively regulates osteogenic differentiation and in vivo bone formation of mesenchymal stem cells. J Cell Biochem. 2015 May;116(5):730-42.
36. Oh HJ, Choung HW, Lee HK, Park SJ, Lee JH, Lee DS,Seo BM, Park JC. CPNE7, a preameloblast-derived factor, regulates odontoblastic differentiation of mesenchymal stem cells. Biomaterials. 2015 Jan;37:208-17.
37. Park HS, Song IS,Seo BM, Lee JH, Kim MJ. The effectiveness of decompression for patients with dentigerous cysts, keratocystic odontogenic tumors, and unicystic ameloblastoma. J Korean Assoc Oral Maxillofac Surg. 2014 Dec;40(6):260-5.
38. Song IS, Park HS,Seo BM, Lee JH, Kim MJ. Effect of decompression on cystic lesions of the mandible: 3-dimensional volumetric analysis. Br J Oral Maxillofac Surg. 2015 Nov;53(9):841-8.
39. Han YS, Jung YE, Song IS, Lee SJ,Seo BM. Three-Dimensional Computed Tomographic Assessment of Temporomandibular Joint Stability After Orthognathic Surgery. J Oral Maxillofac Surg. 2016 Jul;74(7):1454-62.
40. Lee CH, Park HH, Seo BM, Lee SJ. Modern trends in Class III orthognathic treatment: A time series analysis. Angle Orthod. 2017 Mar;87(2):269-278.
41. Kim HY, Lee SJ, Kim SM, Myoung H, Hwang SJ, Choi JY, Lee JH, Choung PH, Kim MJ,Seo BM. Extensive Surgical Procedures Result in Better Treatment Outcomes for Bisphosphonate-Related Osteonecrosis of the Jaw in Patients With Osteoporosis. J Oral Maxillofac Surg. 2016 Dec 15. pii: S0278-2391(16)31283-6.
42. Um S, Kim HY, Lee JH, Song IS,Seo BM. TSG-6 secreted by mesenchymal stem cells suppresses immune reactions influenced by BMP-2 through p38 and MEK mitogen-activated protein kinase pathway. Cell Tissue Res. 2017 Feb 28. doi: 10.1007/s00441-017-2581-4. [Epub ahead of print]

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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