Research output per year
Research output per year
Personal profile
Education
1992-1999: Ph.D., Dept. of Molecular Genetics and Biochemistry School of Medicine, University of Pittsburgh
1985-1991: D.D.S., School of Dentistry, Seoul National University
1985-1991: D.D.S., School of Dentistry, Seoul National University
Professional experience
2003.8 – Present: Full-time instructor (tenure-track), Assistant Professor, Associate Professor, Professor, School of Dentistry, Seoul National University, Seoul, Korea
2001.7 - 2003.7: Postdoctoral Fellow, Skirball Inst. of Biomolecular Medicine, New York University School of Medicine, New York, NY, USA (Advisor: Moses V. Chao, Ph.D.)
2000.9 - 2001.11: Postdoctoral Research Scientist, College of Physicians & Surgeons, Columbia University, New York, NY, USA
1999.8 - 2000.7: Postdoctoral Research Fellow, Harvard Medical School/Dana-Farber Cancer Institute, Boston, MA, USA (Advisor: Charles D. Stiles, Ph.D.)
1995.3 - 1998.3: Teaching Assistant, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
2001.7 - 2003.7: Postdoctoral Fellow, Skirball Inst. of Biomolecular Medicine, New York University School of Medicine, New York, NY, USA (Advisor: Moses V. Chao, Ph.D.)
2000.9 - 2001.11: Postdoctoral Research Scientist, College of Physicians & Surgeons, Columbia University, New York, NY, USA
1999.8 - 2000.7: Postdoctoral Research Fellow, Harvard Medical School/Dana-Farber Cancer Institute, Boston, MA, USA (Advisor: Charles D. Stiles, Ph.D.)
1995.3 - 1998.3: Teaching Assistant, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Research Interests
1. Direct reprogramming of human adult stem cells into specific cell types, such as neurons and glial cells, and delineating underlying mechanisms.
2. In vitro disease modeling to develop precision medicine for neuropsychiatric disorders, such as schizophrenia.
3. Therapeutic applications of directly converted human adults stem cells for neuroregeneration using animal models of neurological disorders, such as Alzheimer's disease and stroke.
4. Signal transduction mechanisms of apoptosis, neuronal differentiation, and nerve regeneration via neurotrophic factor receptors.
5. Stem cell sorting using microfluidic chip.
[ Key words ] adult stem cell, neural differentiation, neuroregeneration, signaling transduction, precision medicine
2. In vitro disease modeling to develop precision medicine for neuropsychiatric disorders, such as schizophrenia.
3. Therapeutic applications of directly converted human adults stem cells for neuroregeneration using animal models of neurological disorders, such as Alzheimer's disease and stroke.
4. Signal transduction mechanisms of apoptosis, neuronal differentiation, and nerve regeneration via neurotrophic factor receptors.
5. Stem cell sorting using microfluidic chip.
[ Key words ] adult stem cell, neural differentiation, neuroregeneration, signaling transduction, precision medicine
Major Research Achievements
1. Hwang M, Song S, Chang MS*, Koh SH*. Glia-Like Cells from Human Mesenchymal Stem Cells Protect Neural Stem Cells in an in vitro Model of Alzheimer’s Disease by Reducing NLRP-3 Inflammasome. Dementia and Neurocognitive Disorders. 19(4):e19 (pISSN: 1738-1495, eISSN 2384-0757) 2021.01. *Co-corresponding author
2. Lee J, Chang MS. Role of DARPP-32 in the Proliferation and Survival of Human Neural Stem Cells. The Korean Journal of Oral Anatomy. 41(1)97-108. (ISSN : 1225–6803) 2020.12.31.
3. Son JW, Park J, Kim YE, Ha J, Park DW, Chang MS*, Koh SH*. Glia-like cells from late-passage human MSCs protect against ischemic stroke through IGFBP-4. Mol. Neurobiol. 56:7617-7630, 2019.05.12. *Co-corresponding author
https://link.springer.com/article/10.1007%2Fs12035-019-1629-8
4. Park HW, Oh S, Lee KH, Lee BH, Chang MS. Olig2-expressing Mesenchymal Stem Cells Enhance Functional Recovery after Contusive Spinal Cord Injury. Int. J. Stem Cells. 11(2):177–186, 2018.10.
https://doi.org/10.15283/ijsc18071
5. Jeon HJ, Park J, Shin JH, Chang MS. Insulin-like growth factor binding protein-6 released from human mesenchymal stem cells confers neuronal protection through IGF-1R-mediated signaling. Int. J. Mol. Med. 40(6):1860-1868, 2017.12.
https://www.spandidos-publications.com/10.3892/ijmm.2017.3173
6. Park J, Lee N, Lee J, Choe EK, Kim MK, Lee J, Byun MS, Chon MW, Kim SW, C. Justin Lee, Kim JH, Kwon JS, Chang MS. Small molecule-based lineage switch of human adipose-derived stem cells into neural stem cells and functional GABAergic neurons. Scientific Reports. 7(1):10166, 2017.08.
https://www.nature.com/articles/s41598-017-10394-y
7. Shin JH, Jeon HJ, Park JH, Chang MS. Epigallocatechin-3-gallate prevents oxidative stress-induced cellular senescence in human mesenchymal stem cells via Nrf2. Int. J. Mol. Med. 38(4):1075-1082, 2016.10.
https://www.spandidos-publications.com/10.3892/ijmm.2016.2694
8. Park HW, Jeon HJ, Chang MS. Vascular endothelial growth factor enhances axonal outgrowth in organotypic spinal cord slices via vascular endothelial growth factor receptor 1 and 2. Tissue Engineering Regen. Med. 13(5):601-609, 2016.10.
http://link.springer.com/article/10.1007/s13770-016-0051-9
9. Chang MS, Yoo JH, Woo DH and Chun MS. Efficient detection of Escherichia coli O157:H7 using a reusable microfluidic chip embedded with antimicrobial peptide-labeled beads. Analyst. 140(23):7997-8006,2015.12.07.
http://pubs.rsc.org/en/Content/ArticleLanding/2015/AN/C5AN01307K#!divAbstract
10. Jung H, Chun MS*, Chang MS*. Sorting of human mesenchymal stem cells by applying optimally designed microfluidic chip filtration. Analyst. 140(4):1265-1274, 2015.02.21. *Co-corresponding author
http://pubs.rsc.org/en/Content/ArticleLanding/2015/AN/C4AN01430H#!divAbstract
11. Jung H, Shin JH, Park YS, and Chang MS. Ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein regulates neuroblastoma cell proliferation through p21. Molecules and Cells. 37(12):881-887, 2014. 12. 31.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275705/
12. Yoo JH, Woo DH, Chang MS*, Chun MS*. Microfluidic based biosensing for Escherichia coli detection by embedding antimicrobial peptide-labeled beads. Sensors and Actuators B 191:211– 218, 2014.02. * Co-corresponding author
http://www.sciencedirect.com/science/article/pii/S0925400513011581
13. Lee EJ, Park HW, Jeon HJ, Kim HS*, Chang MS*. Potentiated therapeutic angiogenesis by primed human mesenchymal stem cells in a mouse model of hindlimb ischemia. Regenerative Medicine. 8(3):283-293, 2013.05.08. * Co-corresponding author
http://www.futuremedicine.com/doi/abs/10.2217/rme.13.17
14. Yang ST, Kim HK, Lim YS, Chang MS, Lee SP, Park YS. A three dimensional observation of palatal vault growth in children using mixed effect analysis: a 9 year longitudinal study. European J. Orthodontics 35:832–840, 2013.
https://academic.oup.com/ejo/article-lookup/doi/10.1093/ejo/cjs104
15. Park HW, Cho JS, Park CK, Jung SJ, Park CH, Lee SJ, Oh SB, Park YS, Chang MS. Directed induction of functional motor neuron-like cells from genetically engineered human mesenchymal stem cells. PLoS ONE 7(4): e35244, 2012.04.05.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035244
16. Park YS, Chang MS, Lee SP. Three dimensional topography of the gingival line of young adult maxillary teeth: curve averaging using reverse-engineering methods. Int. J. Oral & Maxillofacial Implants 26(6):1217-1224, 2011.
http://web.a.ebscohost.com/ehost/detail/detail?vid=2&sid=06279920-5b5a-4377-a592439e320d7848%40sessionmgr4006&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#AN=69533171&db=ddh
17. Yoon EH, Lee KJ, Kim YS, Chang MS, Lee SH, Park CH. Retinoid X receptor acts as a negative regulator in Nurr1-induced dopaminergic differentiation in rat neural precursor cells. Neuroreport 21(18):1162-1166, 2010.12.
http://ovidsp.tx.ovid.com/sp3.26.1a/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&AN=00001756-201012290-00006&NEWS=N&CSC=Y&CHANNEL=PubMed
18. Kim IS, Paik KS, Chang MS, Lee SP. The effect of differential modulation of the N-methyl-D-aspartate receptor on growth and intracellular calcium ion concentration in normal human oral keratinocytes. Tissue Engineering Regen. Med. 7(5):489-500, 2010.10.
http://s-space.snu.ac.kr/handle/10371/81335
19. Park HJ, Park HW, Lee SJ, Arevalo JC, Park YS, Lee SP, Paik KS, Chao MV, Chang MS. Ankyrin repeat-rich membrane spanning/Kidins220 protein interacts with mammalian Septin 5. Mol. Cells 30(2):143-148,2010.08.
http://www.molcells.org/journal/view.html?year=2010&volume=30&number=2&spage=143
20. Park HW, Lim MJ, Jung H, Lee SP, Paik KS, Chang MS. Human mesenchymal stem cell-derived Schwann cell-like cells exhibit neurotrophic effects, via distinct growth factor production, in a model of spinal cord injury. Glia. 58(9):1118-1132, 2010.07.
http://onlinelibrary.wiley.com/doi/10.1002/glia.20992/abstract;jsessionid=B6DB9714660DFDD2E5770A8096B10FFD.f02t02
21. Oh S, Park HW, Cho JS, Jung H, Lee SP, Paik KS, Chang MS. Induction of a neuronal phenotype from human bone marrow-derived mesenchymal stem cells. Int. J. Oral Biol. 34(4):177-183, 2009.12.
http://s-space.snu.ac.kr/handle/10371/73525
22. Cho JS, Park HW, Park SK, Roh S, Kang SK, Paik KS, Chang MS. Transplantation of mesenchymal stem cells enhances axonal outgrowth and cell survival in an organotypic spinal cord slice culture. Neurosci. Lett. 454(1):43-48, 2009.04.
http://www.sciencedirect.com/science/article/pii/S030439400900202X?via%3Dihub
23. Lee Y, Yu JH, Cho JS, Park HJ, Lee SP, Paik KS, Chang MS. Interaction between the p75 neurotrophin receptor and a novel adaptor protein. Int. J. Oral Biol. 33(2):71-76, 2008.06.
http://s-space.snu.ac.kr/handle/10371/69796
24. Sauvageot C, Dahia PL, Lipan O, Park JK, Chang MS, Alberta JA, Stiles CD. Distinct temporal genetic signatures of neurogenic and gliogenic cues in cortical stem cell cultures. J. Neurobiol. 62(1):121-133, 2005.01.
http://onlinelibrary.wiley.com/doi/10.1002/neu.20072/abstract
25. Chang MS, Arevalo JC, Chao MV. Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein. J. Neurosci. Res. 78(2):186-192, 2004.10.
http://onlinelibrary.wiley.com/doi/10.1002/jnr.20262/abstract
26. Chang MS, Sved AF, Zigmond MJ, and Austin MC. Increased transcription of the tyrosine hydroxylase gene in individual locus coeruleus neurons following footshock stress. Neuroscience. 101(1): 131-139,2000.10.
http://www.sciencedirect.com/science/article/pii/S0306452200003523?via%3Dihub
27. Chang MS, Hahn MK., Sved AF, Zigmond MJ, Austin MC and Sherman TG. Analysis of tyrosine hydroxylase gene transcription using an intron specific probe. J. Neuroscience Methods. 94(2): 177-185, 2000.01.
http://www.sciencedirect.com/science/article/pii/S0165027099001375?via%3Dihub
2. Lee J, Chang MS. Role of DARPP-32 in the Proliferation and Survival of Human Neural Stem Cells. The Korean Journal of Oral Anatomy. 41(1)97-108. (ISSN : 1225–6803) 2020.12.31.
3. Son JW, Park J, Kim YE, Ha J, Park DW, Chang MS*, Koh SH*. Glia-like cells from late-passage human MSCs protect against ischemic stroke through IGFBP-4. Mol. Neurobiol. 56:7617-7630, 2019.05.12. *Co-corresponding author
https://link.springer.com/article/10.1007%2Fs12035-019-1629-8
4. Park HW, Oh S, Lee KH, Lee BH, Chang MS. Olig2-expressing Mesenchymal Stem Cells Enhance Functional Recovery after Contusive Spinal Cord Injury. Int. J. Stem Cells. 11(2):177–186, 2018.10.
https://doi.org/10.15283/ijsc18071
5. Jeon HJ, Park J, Shin JH, Chang MS. Insulin-like growth factor binding protein-6 released from human mesenchymal stem cells confers neuronal protection through IGF-1R-mediated signaling. Int. J. Mol. Med. 40(6):1860-1868, 2017.12.
https://www.spandidos-publications.com/10.3892/ijmm.2017.3173
6. Park J, Lee N, Lee J, Choe EK, Kim MK, Lee J, Byun MS, Chon MW, Kim SW, C. Justin Lee, Kim JH, Kwon JS, Chang MS. Small molecule-based lineage switch of human adipose-derived stem cells into neural stem cells and functional GABAergic neurons. Scientific Reports. 7(1):10166, 2017.08.
https://www.nature.com/articles/s41598-017-10394-y
7. Shin JH, Jeon HJ, Park JH, Chang MS. Epigallocatechin-3-gallate prevents oxidative stress-induced cellular senescence in human mesenchymal stem cells via Nrf2. Int. J. Mol. Med. 38(4):1075-1082, 2016.10.
https://www.spandidos-publications.com/10.3892/ijmm.2016.2694
8. Park HW, Jeon HJ, Chang MS. Vascular endothelial growth factor enhances axonal outgrowth in organotypic spinal cord slices via vascular endothelial growth factor receptor 1 and 2. Tissue Engineering Regen. Med. 13(5):601-609, 2016.10.
http://link.springer.com/article/10.1007/s13770-016-0051-9
9. Chang MS, Yoo JH, Woo DH and Chun MS. Efficient detection of Escherichia coli O157:H7 using a reusable microfluidic chip embedded with antimicrobial peptide-labeled beads. Analyst. 140(23):7997-8006,2015.12.07.
http://pubs.rsc.org/en/Content/ArticleLanding/2015/AN/C5AN01307K#!divAbstract
10. Jung H, Chun MS*, Chang MS*. Sorting of human mesenchymal stem cells by applying optimally designed microfluidic chip filtration. Analyst. 140(4):1265-1274, 2015.02.21. *Co-corresponding author
http://pubs.rsc.org/en/Content/ArticleLanding/2015/AN/C4AN01430H#!divAbstract
11. Jung H, Shin JH, Park YS, and Chang MS. Ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein regulates neuroblastoma cell proliferation through p21. Molecules and Cells. 37(12):881-887, 2014. 12. 31.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275705/
12. Yoo JH, Woo DH, Chang MS*, Chun MS*. Microfluidic based biosensing for Escherichia coli detection by embedding antimicrobial peptide-labeled beads. Sensors and Actuators B 191:211– 218, 2014.02. * Co-corresponding author
http://www.sciencedirect.com/science/article/pii/S0925400513011581
13. Lee EJ, Park HW, Jeon HJ, Kim HS*, Chang MS*. Potentiated therapeutic angiogenesis by primed human mesenchymal stem cells in a mouse model of hindlimb ischemia. Regenerative Medicine. 8(3):283-293, 2013.05.08. * Co-corresponding author
http://www.futuremedicine.com/doi/abs/10.2217/rme.13.17
14. Yang ST, Kim HK, Lim YS, Chang MS, Lee SP, Park YS. A three dimensional observation of palatal vault growth in children using mixed effect analysis: a 9 year longitudinal study. European J. Orthodontics 35:832–840, 2013.
https://academic.oup.com/ejo/article-lookup/doi/10.1093/ejo/cjs104
15. Park HW, Cho JS, Park CK, Jung SJ, Park CH, Lee SJ, Oh SB, Park YS, Chang MS. Directed induction of functional motor neuron-like cells from genetically engineered human mesenchymal stem cells. PLoS ONE 7(4): e35244, 2012.04.05.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035244
16. Park YS, Chang MS, Lee SP. Three dimensional topography of the gingival line of young adult maxillary teeth: curve averaging using reverse-engineering methods. Int. J. Oral & Maxillofacial Implants 26(6):1217-1224, 2011.
http://web.a.ebscohost.com/ehost/detail/detail?vid=2&sid=06279920-5b5a-4377-a592439e320d7848%40sessionmgr4006&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#AN=69533171&db=ddh
17. Yoon EH, Lee KJ, Kim YS, Chang MS, Lee SH, Park CH. Retinoid X receptor acts as a negative regulator in Nurr1-induced dopaminergic differentiation in rat neural precursor cells. Neuroreport 21(18):1162-1166, 2010.12.
http://ovidsp.tx.ovid.com/sp3.26.1a/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&AN=00001756-201012290-00006&NEWS=N&CSC=Y&CHANNEL=PubMed
18. Kim IS, Paik KS, Chang MS, Lee SP. The effect of differential modulation of the N-methyl-D-aspartate receptor on growth and intracellular calcium ion concentration in normal human oral keratinocytes. Tissue Engineering Regen. Med. 7(5):489-500, 2010.10.
http://s-space.snu.ac.kr/handle/10371/81335
19. Park HJ, Park HW, Lee SJ, Arevalo JC, Park YS, Lee SP, Paik KS, Chao MV, Chang MS. Ankyrin repeat-rich membrane spanning/Kidins220 protein interacts with mammalian Septin 5. Mol. Cells 30(2):143-148,2010.08.
http://www.molcells.org/journal/view.html?year=2010&volume=30&number=2&spage=143
20. Park HW, Lim MJ, Jung H, Lee SP, Paik KS, Chang MS. Human mesenchymal stem cell-derived Schwann cell-like cells exhibit neurotrophic effects, via distinct growth factor production, in a model of spinal cord injury. Glia. 58(9):1118-1132, 2010.07.
http://onlinelibrary.wiley.com/doi/10.1002/glia.20992/abstract;jsessionid=B6DB9714660DFDD2E5770A8096B10FFD.f02t02
21. Oh S, Park HW, Cho JS, Jung H, Lee SP, Paik KS, Chang MS. Induction of a neuronal phenotype from human bone marrow-derived mesenchymal stem cells. Int. J. Oral Biol. 34(4):177-183, 2009.12.
http://s-space.snu.ac.kr/handle/10371/73525
22. Cho JS, Park HW, Park SK, Roh S, Kang SK, Paik KS, Chang MS. Transplantation of mesenchymal stem cells enhances axonal outgrowth and cell survival in an organotypic spinal cord slice culture. Neurosci. Lett. 454(1):43-48, 2009.04.
http://www.sciencedirect.com/science/article/pii/S030439400900202X?via%3Dihub
23. Lee Y, Yu JH, Cho JS, Park HJ, Lee SP, Paik KS, Chang MS. Interaction between the p75 neurotrophin receptor and a novel adaptor protein. Int. J. Oral Biol. 33(2):71-76, 2008.06.
http://s-space.snu.ac.kr/handle/10371/69796
24. Sauvageot C, Dahia PL, Lipan O, Park JK, Chang MS, Alberta JA, Stiles CD. Distinct temporal genetic signatures of neurogenic and gliogenic cues in cortical stem cell cultures. J. Neurobiol. 62(1):121-133, 2005.01.
http://onlinelibrary.wiley.com/doi/10.1002/neu.20072/abstract
25. Chang MS, Arevalo JC, Chao MV. Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein. J. Neurosci. Res. 78(2):186-192, 2004.10.
http://onlinelibrary.wiley.com/doi/10.1002/jnr.20262/abstract
26. Chang MS, Sved AF, Zigmond MJ, and Austin MC. Increased transcription of the tyrosine hydroxylase gene in individual locus coeruleus neurons following footshock stress. Neuroscience. 101(1): 131-139,2000.10.
http://www.sciencedirect.com/science/article/pii/S0306452200003523?via%3Dihub
27. Chang MS, Hahn MK., Sved AF, Zigmond MJ, Austin MC and Sherman TG. Analysis of tyrosine hydroxylase gene transcription using an intron specific probe. J. Neuroscience Methods. 94(2): 177-185, 2000.01.
http://www.sciencedirect.com/science/article/pii/S0165027099001375?via%3Dihub
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Flow-based microfluidic-chip filtration for efficient sorting and evaluating differentiation potential of human mesenchymal stem cell subpopulations
Jung, H., Nam, S. H., Chun, M. S. & Chang, M. S., May 2025, In: Microchemical Journal. 212, 113527.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Neuroplasticity therapy using glia-like cells derived from human mesenchymal stem cells for the recovery of cerebral infarction sequelae
Lee, E. J., Lee, M. J., Ryu, Y. J., Nam, S. H., Kim, R., Song, S., Park, K., Park, Y. J., Kim, J. I., Koh, S. H. & Chang, M. S., 8 Jan 2025, In: Molecular Therapy. 33, 1, p. 356-374 19 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Link opens in a new tab Scopus citations -
Point-of-Care Diagnostic Devices for Detection of Escherichia coli O157:H7 Using Microfluidic Systems: A Focused Review
Abbas, N., Song, S., Chang, M. S. & Chun, M. S., Jul 2023, In: Biosensors. 13, 7, 741.Research output: Contribution to journal › Review article › peer-review
Open Access29 Link opens in a new tab Scopus citations -
Induction of Nanog in neural progenitor cells for adaptive regeneration of ischemic brain
Jung, G. A., Kim, J. A., Park, H. W., Lee, H., Chang, M. S., Cho, K. O., Song, B. W., Kim, H. J., Kwon, Y. K. & Oh, I. H., Nov 2022, In: Experimental and Molecular Medicine. 54, 11, p. 1955-1966 12 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Scopus citations -
Impaired migration of autologous induced neural stem cells from patients with schizophrenia and implications for genetic risk for psychosis
Lee, J., Song, S., Lee, J., Kang, J., Choe, E. K., Lee, T. Y., Chon, M. W., Kim, M., Kim, S. W., Chun, M. S., Chang, M. S. & Kwon, J. S., Aug 2022, In: Schizophrenia Research. 246, p. 225-234 10 p.Research output: Contribution to journal › Article › peer-review
6 Link opens in a new tab Scopus citations